Sexual Reboot Forum › Does anyone have high Testosterone and still have SE
This topic contains 8 replies, has 1 voice, and was last updated by Gerry 3 years, 10 months ago.
June 27, 2014 at 12:38 pm #108754
Does anyone on here have typical symptoms of Sexual exhastuion such as premature ejac, erectile dysfunction, eyefloaters, earbuzzing, frequent urination, etc etc but have a high testosterone level? If so can you please tell me what you measured at. thanks.There is another way that you can stop porn addiction, chronic masturbation and recover your sexual health without fighting it with willpower. With the right mindset you won't even relapse. You can learn more about the recovery program hereJune 27, 2014 at 4:47 pm #108817
i measured a little over 1000 when I was in my trough of sexual exhaustion. I had abstained for like a week after masturbating a lot right before I stopped though, which may have boosted it. I also got tested first thing in the morning when levels are highest. I hear testosterone levels are constantly fluctuating so its hard to say what my normal levels would be like.June 27, 2014 at 11:52 pm #108895
alex, you had a very high level of Testosterone but still had SE??June 28, 2014 at 7:42 am #108987
the thing is sex/masturbation affects your testosterone levels long after the act. i think i read that testosterone peaks a week after. so basically i was masturbating like crazy and probably had lower levels, but then when i stopped they suddenly rose a lot. my theory is that masturbation boosts your testosterone levels and is good for you for a while after, but in the longrun will burn you out. i doubt that my testestorone levels are that high anymore.
i feel like neurotransmitters play much more a role in the sexual exhaustion for me. its definitely hormonal as well thoughJune 28, 2014 at 10:44 am #109038
I am trying to understand the relation between the nervous system and Testosterone. My understanding is that we need to power up the nervous system and that will eventually promote endocrine function (including testosterone). But there is also this thing that Testosterone is needed to charge the nervous system… this seems so confusingJune 28, 2014 at 5:29 pm #109163
yeah… its extremely complicated. i’m actually taking molecular, cellular, and developmental biology (at the university of michigan) right now and that shit is soooo fucking hard. it would honestly blow your guys’ mind if you took a look at the notes- and it all has to do with what were dealing with. even at this advanced of a level, were still just beginning to uncover whats really going on.
im taking this course on nutrition in the fall by the way so if u guys have any questions about supplements or anything let me know and i can get u very accurate, in depth answers.June 29, 2014 at 1:57 am #109242
That’s great man. You must be really smart to do this course at a reputed university. Please do let us know if you find something.June 29, 2014 at 10:58 am #109322
thanks bro.. all this shit is honestly whats been motivating me to do well here (and to get here in the first place). it drives me crazy how the internet is full of scams and doctors are completely ignorant while we are forced to live in this horrible condition. hopefully one day i can make a difference so others can cope with the shit we have to blindlessly fight. if i find anything thats potentially beneficial to you or others in the meantime i’ll let you guys know whats upJune 29, 2014 at 2:47 pm #109354
If a male is hypogonadal for an extended period of time, then the first exposure to testosterone replacement can be exhilarating. Then it eventually goes away.
Here is a simplification of what may be happening:
Testosterone increases dopamine signaling in the brain. Dopamine signaling promotes sex drive, attention, interest in activities, elevates mood, and is calming in effect since it also reduces norepinephrine signaling. Without testosterone, there may be an increase in dopamine receptor concentration due to the loss of dopamine signaling.
Testosterone, itself, has a calming effect on the brain. It helps reduce norepinephrine signaling. Losing testosterone loses another of the control signals on norepinephrine production.
The loss of testosterone production is also accompanied by a loss of testicular thyroid releasing hormone production. This results in a reduction in thyroid hormone production. This results in a reduction in metabolism and energy. The brain compensates by increasing norepinephrine production to increase energy. This increase in norepinephrine signaling can promote insomnia, irritability, anxiety. It also does not usually improve energy well.
Over time, with aging, thyroid hormone production is reduced. This compounds the problem of thyroid loss accompanying testosterone production loss, including a further increase in norepinephrine signaling to compensate for the loss.
Testosterone, overall, is an anti-inflammatory signal and helps govern adrenal function, preventing excessive production of cortisol. Without testosterone, under increased norepinephrine signaling levels, high cortisol production may occur – which may or may not cause problems.
The elevated norepinephrine signaling may then be accompanied by pro-inflammatory cytokine signaling as the brain becomes chronically elevated by stress signaling/norepinephrine. Over time, this may then cause hypothalamic-pituitary-adrenal dysregulation with low cortisol production.
Estradiol, functioning as an MAO, increases serotonin greater than norepinephrine. It promotes competitiveness, drive, sex drive, aggressiveness. Without testosterone, however, and the dopamine increase it promotes, Estradiol would tend to flatten sex drive and promote irritability and aggression, anger, instead. Unless testosterone production is very low, Estradiol can be maintained since so little in relationship to testosterone, is needed in men. The relative change in signaling strengths of each poses problems of excessive estrogen. This includes increased thyroid binding globulin and reduction of free thyroid hormone signals. Excess estrogen, by increasing serotonin excessively, may reduce sex drive.
Norepinephrine is important for sexual function. It promotes the high and excitement that accompanies sex drive / libido. But in excess, it does not. It causes tension, stress, distress, anxiety, irritability, which lowers sex drive. To increase norepinephrine, the brain may reduce serotonin, GABA, then dopamine production – causing problems with deficiencies in serotonin, GABA and dopamine.
Excessive norepinephrine production also causes insulin resistance. The increase in insulin production that results is pro-inflammatory. It also further reduces testosterone production. Insulin also promotes fat storage. The resulting increase in fat results in an increase in Leptin and other pro-inflammatory signals from fat cells.
And so on and so on. These are some of the changes that permeate the system from the loss of testicular testosterone production. Some are added to by changes in the metabolism of the other cells which produce other signals such as thyroid hormone, through the process of aging or with nutritional problems or with genetic predisposition to other signaling or metabolic problems or through structural changes such as the loss of cells in the hippocampus and other brain structures.
So what happens when testosterone is replaced?
There is a reversal of some of the initial signaling problems.
Because there is a larger number of dopamine receptors from the dopamine signaling deficit caused by the loss of testosterone, there is dopamine supersensitivity to the surge of dopamine signaling that accompanies the increase in testosterone with replacement. This can cause a high – with heightened sex drive, alertness. and an elevated mood.
Testosterone would also free up thyroid hormone by reducing thyroid binding globulin, reversing estrogen’s effects, improving function from this angle. This would improve energy
Testosterone would then reduce excessive norepinephrine signaling, which as it comes more in normal physiologic strength, helps dopamine in providing a higher level of libido, sex drive, and an emotional high.
The testosterone to estrogen ratio would improve, reducing effects of excess estrogen. Insulin signaling is reduced. The body becomes less in an inflammatory state.
The person feels better, if not feels a high from the initial treatment with testosterone.
Over time, however, with increased dopamine signaling, dopamine receptor production is reduced back to a normal amount. Dopamine, as the reward signal, the feel good signal, can’t be elevated for a prolonged period of time excessively, without problems occurring. It no longer becomes a reward signal if it is elevated for a prolonged period of time. Tolerance, through receptor reduction, occurs.
After the initial high, other problems also occur.
Exogenous testosterone suppresses testicular thyroid releasing hormone production. This reduces thyroid hormone production, undoing the initial increase in free thyroid hormone that testosterone caused. If there is hypothyroidism in the first place, this exacerbates that problem.
If there are other neurotransmitter, hormone, cytokine signaling problems or metabolic-nutritional problems outside of hypogonadism, these may complicate or undo what testosterone initially did.
If the man aromatizes testosterone to estrogen excessively, problems with excessive estrogen occur. If aromatization is not enough, then problems with too little estrogen occur. In either case, sex drive is impaired.
Thus, the hypogonadal man returns to Earth. And the initial high is lost.
Romeo B. Mariano, MD, physician, psychiatrist “
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