Sexual Reboot Forum › How too minimise paracetamoltylenol liver side effects
This topic contains 25 replies, has 1 voice, and was last updated by Jamie 6 years ago.
September 26, 2013 at 10:35 am #9333
Hope all is well
Ive been thinking about making a thread here on how too minimise liver
damage side effects from taking paracetamol/tylenol. A few people have
been emailing me about taking paracetamol and Nirvana has asked couple
times on how too potentially minimise or even negate all possible liver sides
from happening via tylenol.
I did make a thread on how a safe med(paracetamol) cured my PE and so
far its been tremendous not just for PE but other things like erection
strength, compares to viagra but with the crazy stamina effects,libido
boost, much larger flacid hang can finish and erection+sex drive doesnt
subdue . Other things not related too SE/PE have also improved training
recovery, muscles less sore etc
Adrenals and naturally testosterone levels may have improved as well
since i have successfully weaned off cortef+pregnenolone too more than
50% of previous dose before tylenol. Also came off TRT recently
and im currently trying a natural TRT restart
with clomid which i have previously failed before several times
due too testosterone levels not holding after comming off, clomid, hcg,
Anyways the main thing i didnt like about my thread on how
a simple safe med like tylenol cured my pe was the word *safe*.
My conscience kicked in and i want too make sure anyone who
has taking it and experienced benefits or is thinking of taking it
long term please take your time too read this info on how too minimise
liver sides from tylenol.
Lets start with how paracetamol damages the liver.
Reports have been taking that normal dosing at 1000mg every 6hrs on
and off for occassional flu/Arthritis purposes too a toxicity dose at
10000g can* all cause some kind of side effect either to most extreme
effects like liver failure too death or much lesser effects like slight
temporary liver toxicity symptoms.
This is caused by the tylenol metabolite, N-acetyl-p-benzoquinoneimine
(NAPQI) which depletes the liver’s natural antioxidant glutathione levels
and directly damages cells in the liver, leading to liver failure.
Typically on a normal dose of 1g x4 a day for 2weeks one can expect
an increase in alanine transaminase from their liver too about x3 of the norm.
At this dose it would be unlikey too cause liver failure which is why
for long term benefits Iam on a smaller eod dose of 500-1000mg. Using this
much smaller dosing and also the every other day dosing im allowing
a much longer period for the alanine transaminase too not be built up in
the liver to the x3 threshold even though 3x the norm of alanine transaminase
levels in the liver is not nearly a liver toxicity level but have too factor in
long term effects as well so want too make sure too keep it low
as possible yet experience the PE and sexual benefits.
Since the tylenol metabolites N-acetyl-p-benzoquinoneimine depletes
glutathione levels it would be wise too keep glutathione levels healthy
or even high since this metabolite lowers glutathione depending on ones
current liver health via how the different methylation pathways
are performing in building up glutathione.
Nac is the easiest option too do this but it is only
1 methylation route too increase glutathione and is invidualistic
on how much NAc is converted too glutathione. Also have too factor
in roughly 1800mg a day is the highest dose one can take before
there are no longer anymore noticeable benefits for the liver via
**Taking glutathione directly too increase glutathione is not possible
since its destroyed in the gut straight away.**
Here are some of the other methylation pathways the liver can take too
boost glutathione levels by boosting :
b6/p5p (p5p preferable since majority are unable too convert too p5p)
folic acid/b9 (L-Methylfolate for some who are unable too convert to this active form)
One way too tell which of your liver methylation pathways are needing a boost or if one pathway is needing too be unclogged is by taking urine vitamin+mineral+ amino acid test. Also would recommend histamine and homocysteine blood tests as well since one could have healthy levels of the above but may still need eitherTMG+methionine or SAM-e too unblock/open the homocysteine pathway by breaking or metabolising homocysteine properly,efficiently & consistently.
If you look at the human body of how methylation should work from this
diagram here in the pic 1/4 page down you can see how the cycle should work :
Also would be best too test for blood histamine and homocystiene since both of these will slow down methylation or block the pathways and grind the liver too a halt causing it too be backed up even more dispite adding many methylating boosting supplements.
Tmg can lower homocystiene levels taking along with amino acid methionine.
However this method also lowers cysteine levels so NAC would have too
be supplemented even more so glutathione isnt lowered even more from
this method plus the tylenol.
Although Sam-E will do a much better job but with an added price tag
in breaking down homocysteine levels than the methionine and Tmg method.Sam_e is also the best supplement on earth too boost glutathione levels but is very expensive and usually only needed if one is severely
under methylated/liver is underperforming, liver bile not flowing properly,
not clearing toxins,estrogens,fats, not making use off nutrients
from food, supplements etc
If you have healthy levels of all from the above from urine test and blood
then your liver is in the average 50% of population that you are neither under or overmethylator. 40% or so people are under and 10% or so are
over meaning these overmethylators were born with good genes or took care of themselves of both They complain about eating lots of food be it clean or junk and cant put on anyweight/fat, have lots of energy, rarely get sick, if they workout theyburn fat and put on muscle quickly but the unfortunate majority like myself when i was sick complain of opposite. ;(
So all n all if you want too lessen or nullify the liver
damage from tylenolto your genetic potential then take the tests and go from there. I think a simple vitamin+mineral+amino acid test cost me 70bucks and all u do is pee in sample, morning fasted first thing, catch it mid flow, send back and results in 1-2 weeks.
The homocystiene and hsitamine blood testing will need permission from
a local doc.
I have a theory but no proof in how tylenol helps me and couple others
so far in such dramatic fashion but not others.
I believe it comes down too the liver
methylation pathway on how much glutathione one is producing,also if one
or many of the pathways are blocked. I think that if one has low
glutatione levels or has a blockage in a pathway then the paracetamol PG2/Cox2 inhibtory actionmay not be as effective since its being passed through an unhealthy liver where the glutathione levels are lower than norm and one has many methylation blockages or even worse a fatty liver and has been backed up for a while and needs too be cleared for tylenol too be properly/fully assimilated.
I have no proof here but science says the ones who have experienced
liver failure, transplant & even death are the ones who usually abused
paracetamol but not always but it always points back too glutathione levels
being the culprit for these liver side effects.
I was going too mention some of my experiences too back up this some morebut wanted too get the technical aspects across as i felt it was more important too make sure the liver isnt damaged from long term paracetamol.
Its late here 6am took me a while too finish this and i havent been studying up on this much recently so there may some errors here and there so anything doesnt make sense please share:)
Happy holidays everyone!! Have a good one :DDDThere is another way that you can stop porn addiction, chronic masturbation and recover your sexual health without fighting it with willpower. With the right mindset you won't even relapse. You can learn more about the recovery program hereSeptember 26, 2013 at 10:35 am #9335
If you check out the original thread a study was posted talking about why Paracemetol works for PE.
However I still question it’s affects on serotonin and potentially over long-term use lowering production.
Doesn’t matter.. it doesn’t help me.September 26, 2013 at 10:35 am #9337
Thanks for the heads up Chris.
You’re a life saver.
I want to get this test done for liver function just for curiosity. The only tests I have to work with though are blood – sex hormones and thyroid, saliva – adrenals, and urine – neurotransmitters. So you think the histamine levels in the neurotransmitter will be enough to tell the story? or what test should I order? one specifically for liver function?
So as you heard the Tylenol’s been doing wonders for me too. The thing is, if I DON’T take tylenol for a day, things return to hard flaccid right away, unlike you. Which shows that the root – be it adrenals or testosterone.. is still not addressed. So I still need to take care of that, and when that’s fixed I’m sure I’ll need smaller doses of tylenol than now to keep PE away. Right now I need 1000 mg a day at a minimum and to be taking it consistently for all symptoms to be gone and things to return to 100%. Hopefully when I address adrenals or w/e.. 1000 eod will be more than enough.
But I def plan on taking this long term. The way it gives you control over PE is amazing. I still haven’t had sex on it though. Ya man feels like popping a viagra but even better haha.
I got 2 more questions for you Chris:
1. You know if anything can be done to prevent kidney damage? Or are the kidneys at harm at all?.. it’s great that liver can be prevented.. what about kidneys though..
2. Do you drink booze? how often?
I read that mixing tylenol and booze is very hard on the liver. And that blows. Basically means that preferably I shouldn’t drink. But that’s not gonna happen. I’m cutting down though..
You think if I keep taking NAC at high doses I can afford to drink like once a week? maybe once in 2 weeks?.. I don’t mean get hammered.. maybe 5-6 shots.. maybe out with a girl..
Or you think drinking on top of tylenol will just destroy the liver?September 26, 2013 at 10:36 am #9338
You guys realize that many people take Tylenol their entire lives right? Your concern seems far too high.September 26, 2013 at 10:36 am #9342
Sure, but I’m just saying like, people with arthritis are taking it constantly, and my dad who had a double lung transplant has been on it for 7 years straight now.
The real thing you guys need to worry about is either gaining a tolerance to it, or it affecting serotonin levels.September 26, 2013 at 10:37 am #9344
when i warned them that time…no one showed any interest in what i said
how funny life is……September 26, 2013 at 10:38 am #9348
Yeah cycling meds actually works as he said. But you may have to go upwards of a month without tylenol in order to reset the system which means a month of PE.September 26, 2013 at 10:38 am #9350
you need to deal with the root cause of high PG2….theres a reason for it and you have to find it. Once you do that ull be able to much better naturally control pg2 and use much smaller doses of tylenol and or use herbal stuff.
The only way for a long term solutionSeptember 26, 2013 at 10:38 am #9352
well I tried the tylenol and it didnt do nothing for meSeptember 26, 2013 at 10:39 am #9353
try evening primrose oilSeptember 26, 2013 at 10:40 am #9357
try some dextromorphan (anti cough med) and report backSeptember 26, 2013 at 10:40 am #9358
Anyone trying tylenol – make sure you take the right one. it’s the Tylenol Cold Day Extra Strength – yellow tablets.. not the sinus one and nothing besides extra strength.
The cold extra strength day has 500 mg Acetaminophen and 10 mg Dextromethorphan.. which is what we need.September 26, 2013 at 10:41 am #9360
You guys should be taking both and you should be taking within the ranges specified by that study, that’s why it was posted.September 26, 2013 at 10:41 am #9362
2xparacetamol 500 mg + 30 mg dextromethorphan
i was on fire!
trying again tonight, i literally have a cough so i need syrup anywaySeptember 26, 2013 at 10:41 am #9363
Pimp, is dextromethorphan sold in places like walgreens or is it only included in tylenol cold ? I may try it.September 26, 2013 at 10:41 am #9365
it’s a regular cough syrup, can be had at local pharmacy and perhaps walmart? i am from europe and it can be had otc hereSeptember 26, 2013 at 10:42 am #9367
Also congrats Pimp! It is nice be able to have enjoyable sex again!September 26, 2013 at 10:42 am #9369
please review this article:
it seems hydrocodone (brandname vicodin i believe) was not responsible for the liver damage but tylenol had more effect
hydrocodone is an opiate and also a cough suppressant, so maybe we should be looking into this?
is it the same as tramadrol?September 26, 2013 at 10:42 am #9371
vicodin seems popular, this is what i found elsewhere:
I’ve suffered from premature ejaculation for a while, my doctor told me it was probably a mental problem, but I disagree with that since I can go about 10 or 15 minutes if I’m drinking, or on an opiate like a pain killer. When I’m on these drugs I’m not a totally different person mentally, so I don’t think that is the reason for my problems. Also, I can go longer after I’ve ejaculated once already. The stop and go method and kegals haven’t really helped me. This brings me to the conclusion that it’s biological because I’m very comfy with my girlfriend and I’ve had this problem for years, I also have the problem when I masturbate.
* Clearly I can’t drink all the time or take pain meds before sex habitually because it isn’t healthy. Finally I found a herbal opiate mimicker called “Kratom”, it’s completely natural, it’s basically just dried up leaves from a certain tree that grows in various parts of the world. It’s completely legal in America and you can order it on the internet from various vendors. I take about 6grams of the fine powdered Kratom and it feels like I took a vicodin. Kratom does the same thing that pain meds do for delaying my ejaculation. I last probably 3 times as long with it, so probably 10 or 15 minutes during intercourse. Kratom has been around for thousands of years and it is much less habit forming then other commonly abused prescription drugs. Look it up information on it at Erowid.com, its effects are variable on different people so don’t get your hopes up too much.
Also there’s a new short acting SSRI on going through the FDA called Depoxetine, through trial experiments it’s very effective, but I don’t like habitual use of synthetic drugs, especially SSRI’s, so I don’t recommend it. I hope this helps you.September 26, 2013 at 10:43 am #9373
combine with NAC or something for glutathion?
Paracetamol hepatotoxicity is, by far, the most common cause of acute liver failure in both the United States and the United Kingdom. Paracetamol overdose results in more calls to poison control centers in the US than overdose of any other pharmacological substance. Signs and symptoms of paracetamol toxicity may initially be absent or vague. Untreated overdose can lead to liver failure and death within days. Treatment is aimed at removing the paracetamol from the body and replacing glutathione. Activated charcoal can be used to decrease absorption of paracetamol if the patient presents for treatment soon after the overdose. While the antidote, acetylcysteine, (also called N-acetylcysteine or NAC) acts as a precursor for glutathione, helping the body regenerate enough to prevent damage to the liver, a liver transplant is often required if damage to the liver becomes severe.
There are tablets available (brandname in the UK Paradote) that combine paracetamol with an antidote (methionine), to protect the liver in case of an overdose.
In June 2009, an FDA advisory committee recommended that new restrictions should be placed on paracetamol usage in the United States to help protect people from the potential toxic effects. The maximum dosage to be consumed at any given time would be decreased from 1000 mg to 650 mg, while combinations of paracetamol and narcotic analgesics would be prohibited. Committee members were particularly concerned by the fact that the present maximum dosages of paracetamol had been shown to produce alterations in hepatic function. The FDA has not implemented their recommendations as of October 2010.September 26, 2013 at 10:43 am #9374
DionSeptember 26, 2013 at 10:43 am #9376
AnibalSeptember 26, 2013 at 10:44 am #9378
Good findings .
Ok the first study
is pretty much inconclusive… the doc says tylenol COULD be responsible for the elevated liver enzymes but at the same time it COULD be something else… and that’s where it ends… weird :S
Somebody actually took 10 grams of tylenol? god damn… that’s 20 tylenols in a day… what did you think was gonna happen…
They don’t recommend taking tylenol for more than 3 consecutive days… that sounds pretty scary..
The ‘Kratom’ story is interesting.. maybe it works just as well.September 26, 2013 at 10:44 am #9380
Great findings. Thank you for sharing these.September 26, 2013 at 10:45 am #9382
yeah i knew about the tramadrol
i believe it’s an opiate pain killer which means it can become addictive which i am afraid of, and also that you need more to regain same effect
just read kratom is also prone to withdrawal symptoms like any other drug, but reports on forums suggest that a low dose kratom daily isn’t that hard of an addiction
suggesting the painkiller meds are more addictive
so what if we would make a low dose capsule, i know this works for me:
loratadine (anti histamine, 10 mg and viagra no wood, 5 mg and viagra 9 out of 10 times good wood, so say 2.5 mg loratadine)
paracetamol 500 mg
dxm 30 mg
l-dopa 100 mg
5-htp 50 mg
i bet this would be an awesome stackSeptember 26, 2013 at 10:45 am #9384
A small minority of users use kratom to prolong sexual intercourse.
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