norepinephrine post by mariano from meso

Sexual Reboot Forum norepinephrine post by mariano from meso

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    Originally Posted by griffinannie

    Can high nor-ep cause chronic ED ? If so , how? What can be done?

    High norepinephrine levels (or relatively high norepinephrine levels compared to the other neurotransmitters) can cause erectile dysfunction (chronic or otherwise).

    Norepinephrine is the primary signal in the brain for stress. It is a excitatory neurotransmitter. It keeps a person awake. It can help improve attention. It causes an increase in ACTH production, which then drives adrenal hormone production. A spike of norepinephrine triggers orgasm/ejaculation in men. Norepinephrine is the primary chemical messenger of the sympathetic nervous system (the system that responds to fight-or-flight, stressful situations).

    When a person has chronically high norepinephrine, it can cause anxiety or irritability. It can eventually cause adrenal depletion, fatigue, or frank adrenal insufficiency. This can then lead to erectile dysfunction, loss of libido, sexual dysfunction.

    To keep norepinephrine levels high, the brain may have to lower the production of dopamine, which can lead to loss of libido and erectile dysfunction. Lowered dopamine production, itself, can reduce testosterone production (though high norepinephrine can raise it – causing a wash if the balance is maintained). Lower testosterone can lead to erectile dysfunction. Lowered testosterone production can lead to insulin resistance and further metabolic cascades that can cause erectilve dysfunction and lack of libido.

    Chronically high norepinephrine production in the absence of other neurotransmitter, hormone, cytokine problems, can lead to premature ejaculation – since it doesn’t take much to get a higher norepinephrine spike to trigger ejaculation.

    Chronically high norepinephrine can raise blood pressure. This leads to long-term consequences, including renal dysfunction and erectile dysfunction.

    What can be done is to either directly address the high norepinephrine production (e.g. with a serotonergic, anxiolytic, mood stabilizing, beta-blocking medication or others), or treat the consequences – such as adrenal fatigue (where the higher cortisol levels from treatment can help reduce via a feedback loop in the brain to lower CRH production, to lower norepinephrine levels), or treat the underlying cause of higher norepinephrine levels (which can include psychological stress, trauma, mental illness, thyroid dysfunction, hypogonadism, insulin resistance, infection or other chronic physical illness, etc.). In a way, a global treatment once assessment occurs, needs to be done. I usually don’t see a single substance (drug, hormone, or nutrient, or even herb) working. There are many entrypoints to dysfunction when a single hormone/neurotransmitter is out of whack in function. What I usually see are multiple hormone/neurotransmitter/cytokine problems as a consequence.

    Read more from the MESO-Rx Steroid Forum at: [MOD EDIT: URL Removed]

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    Good find. This guy really knows his shit.



    I believe that to be the route of my problems…



    Norepinephrine is the primary signal for stress/distress. It triggers the negative emotions of anxiety/fear and irritability/anger.

    Norepinephrine is also the primary signal for wakefulness. When inappropriately timed, one has insomnia.

    Norepinephrine is also one of the signals for thermogenesis – body heat production. It can make a person feel hot. Usually, this is an illusion of being hot from the expectation it is going to work. Unfortunately, human beings have very few brown fat cells, unlike other mammals. And, if there are metabolic problems impairing ATP production, cells can’t respond to norepinephrine in heat production. Thus, norepinephrine may be ineffective in raising body temperature. However, the brain has the unconscious expectation it is going to work, thus the illusion of heat – a hot flash.

    Norepinephrine signaling triggers sweating, after translation to acetylcholine prior to triggering sweat gland activity.

    Norepinephrine signaling increases corticotropin releasing hormone (CRH) production, which then increases ACTH production. ACTH is created from a longer-protein which contains ACTH and melanocyte stimulating hormone. When ACTH is cleaved off this pro-hormone, melanocyte stimulating hormone is also cleaved off. Melanocyte stimulating hormone makes various parts of the skin darker – such as the eyelid skin, crotch area, palmar creases, neck, etc. etc. In ACTH secreting pituitary tumors, so much melanocyte stimulating hormone is produced, the affected person ends up having an all-over deep tan.

    Norepinephrine and CRH are in a positive feedback loop. CRH is not only a hormone but also a neurotransmitter produced by various parts of the nervous system. CRH increases norepinephrine production. Norepinephrine increases CRH production. This positive feedback loop can spin out of control resulting in excessive norepinephrine signaling unless other signaling systems, such as cortisol, can control the loop by reducing either CRH or norepinephrine. Excessive norepinephrine can lead to anxiety attacks or panic attacks – a more severe form.

    Thyroid hormone – either high or low – can increase norepinephrine production through effects on other signaling pathways.

    Suboptimal cortisol production can result in failure to break the CRH-Norepinephrine positive feedback loop. This, in some people can lead to anxiety attacks.

    Excessive supraphysiologic cortisol production can lead to excessive norepinephrine signaling through other signaling pathways.

    Problems in other signaling pathways and metabolic problems can lead to excessive norepinephrine signaling. Thyroid and cortisol are only two of many other signals that influence norepinephrine signaling. When thyroid and cortisol are optimized yet anxiety attacks continue, then these other signaling systems and metabolism have to be evaluated for problems.

    For example, excessive estrogen signaling can directly and indirectly (through intervening pathways) lead to excessive norepinephrine signaling if other control signals for norepinephrine are not in place.

    Mental function problems – such as anxiety – are often a summation of many signaling problems and/or metabolic problems, not just the effect of single signal problems.

    Mental function is highly preserved, protected by redundant system since it is necessary for survival in the wild. It takes many problems acting together to impair mental function.

    When a person has a mental illness, it is often caused by multiple underlying problems.

    This is why single treatments often do not work fully or even well. For example, when using a serotonin reuptake inhibitor for panic attacks, often the best care scenario is that 70% of patients still have panic attacks despite treatment. Serotonin is only one of the signals that controls norepinephrine.



    very informative. speaks volumes I guess. Thanks Js for sharing.

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