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Sexual Reboot Forum post by Dr. M

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    Another precise and clear informative post by Dr Mariano on how and what

    neuros/hormones causes depression :

    Originally Posted by chip douglas


    Hi Marianco,

    In his last book titled : ”Younger you”, Dr. Eric Braverman [MOD EDIT: URL Removed] writes that Serotonin deficiency will often lead to depression and and as a result lead to other health issues such as :

    Accelerated calcification

    Lower sex drive, triggering andropause and menopause

    Lowering of Testosterone leading to andropause

    Lower estrogen, progesterone

    Weaken the immune system

    Accelerate skin aging

    A. By Dr Mariano

    This is one of several possible pathways. But it is too vague – the links are not clearly made. The problem is that there is no explanation as to why this all occurs – for example, what pathways are involved.

    Looking at things from my point of view – that the mind is a fluid circuit involving multiple chemical messengers and multiple possible metabolic cascades/pathways:

    If one specifically kills off serotonin-producing neurons – for example, by using Ecstasy or Fenfluramine (part of the FenPhen tablet that is now off the market) – then one can envison one possible cascade (out of many):

    1. A serotonin deficit leads to a reduction in thyroid hormone production (which depends on serotonin, one of many cofactors).

    2. A serotonin deficit also leads to loss of control over norepinephrine production (since serotonin neurons help reduce norepinephrine production from norepinephrine neurons) – leading to an increase in norepinephrine production.

    3. The reduction in thyroid hormone production leads to a reduction in steroid hormone production from the testes – particularly a reduction in testosterone production, then estrogen production.

    4. The increase in norepinephrine production leads to an increase in ACTH production, which leads to an increase in adrenal cortex hormone production.

    5. Over time the chronic increase in norepinephrine production leads to adrenal fatigue, and reduced adrenal cortex hormone production.

    6. Adrenal fatigue leads to a reduction in progesterone, DHEA, Cortisol, Pregnenolone, Aldosterone, testosterone, estrogen production.

    7. Adrenal fatigue, lower thyroid hormone levels, lower testosterone levels leads to even higher norepinephrine production.

    8. Lower thyroid and adrenal hormone production leads to an increase in inflammatory versus anti-inflammatory signals on the immune system, leading to an increase in inflammatory responses.

    9. The increase in inflammatory responses leads to the development of atherosclerosis – and calcification – of the arteries.

    10. The increase in inflammatory responses versus antiinflammatory responses leads to weakening of the immune system – inflammation, for example, in barrier cells such as the skin, allows pathogenic bacteria and viruses an easier entry into the body. Inflammation precedes infections and various diseases.

    11. The reduction in thyroid, DHEA, testosterone and the general increase in inflammatory signals leads to a reduction in IGF-1 production from growth hormone in the liver.

    12. The reduced production of estrogens, IGF-1, and thyroid hormone leads to an increase aging of the skin.

    13. Lower thyroid hormone can lead to lower serotonin, lower dopamine, lower GABA production, and a further increase in norepinephrine production.

    14. Low thyroid, testosterone, GABA, dopamine, adrenal hormone production, and higher norepinephrine production can lead to a reduction in sex drive.

    I do not necessarily agree with the notion that lowering sex drive triggers andropause or menopause, or that lowering testosterone leads to andropause. These are overgeneralizations.

    Andropause is an age-related phenomenon – due to age-related decline in the pituitary’s ability to make LH or due to age-related decline in the testes’ ability to produce testosterone.

    Andropause is not necessarily related to a serotonin deficit – since a serotonin deficit can occur at any age, be present due to genetics (thus one is born serotonin deficient), or be induced due to drug abuse or medication adverse effects, etc. If Andropause is specifically due to a serotonin deficit, this would lead to the nonsensical scenario of a male newborn with born with a serotonin deficit being diagnosed with andropause.

    Similarly, menopause is an age-related phenomenon, not necessarily related to a serotonin deficit. Rather is is related to the end of the ovaries’ ability to produce eggs. Women are born with a limited number of eggs. If the last egg is ovulated or the egg-shell surrounded the woman’s eggs become so fibrous over time that the egg cannot get out, then menopause starts.

    Also, the pathway delineated above is just one of several possible scenarios. Thus any given person may take a different path with a different outcome.

    For example, if a serotonin deficit occurs, then dopamine production is unleashed since serotonin production leads to a reduction in dopamine production from dopamine producing cells. Serotonin and Dopamine are joined at the hip in production.

    The increase in dopamine may then lead to an increase in testosterone production, an increase in sex drive, etc. An increase in testosterone production may then increase thyroid hormone production (though it can also reduce it in some men). The end-point may then be very different or is opposite to what was previously described.

    Lower serotonin may lead to depressed mood, but then it can also lead to a non-depressed mood depending on how high dopamine and it’s metabolic cascades go. Lower serotonin may then alternatively lead to violent behavior in some people (e.g. in XYY chromasome disease, the men have lower serotonin levels and tend to be more violent).

    Given the possible pathways involved, it would then be up to the physician treating the patient to try to see which pathways the patient may be going through. This allows the physician to then see where the pathophysiology of illness is, then custom design a treatment to address that particular patient’s situation. One has to dance with the patient’s responses. To a physician, this is like playing jazz. The ability to improvise is the mark of a good physician.

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    Wow I donno where you found this.. great stuff.

    The pathway that he described in detail is exactly what could have happened to me. He mentioned this could happen after doing ecstasy. I’m pretty sure test results will match everything he mentioned – high norepinephrine – lowered adrenals – lowerish thyroid…

    So basically using this guideline I’ll try to supplement for everything I can to reverse what happened. And if its not enough then its time for hormone intervention and seeing the doc himself.



    .. just hope the ecstasy didn’t ‘kill off’ a lot of serotonin producing neurons. That doesn’t sound too good.



    ya werd….honestly if you type shit it on google like like serotonin or adrenal fatigue and add Dr. Mariano chances are theres some link on it. He seriously knows everything . He has posts like this all over the place. But ya werd if you cant figure it out on your own go see him yourself.

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